Endophenotypes in schizophrenia: A selective review
نویسندگان
چکیده
منابع مشابه
Intermediate phenotypes in schizophrenia: a selective review
Studies aiming to identify susceptibility genes for schizophrenia and other complex psychiatric disorders are faced with the confounds of subjective clinical criteria, commonly occurring phenocopies, significant between-subject variability of candidate traits, and the likelihood of allelic and locus heterogeneity that has been shown to define the genetics of other complex human brain and somati...
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The search for liability genes of the world's 2 major psychotic disorders, schizophrenia and bipolar disorder I (BP-I), has been extremely difficult even though evidence suggests that both are highly heritable. This difficulty is due to the complex and multifactorial nature of these disorders. They encompass several intermediate phenotypes, some overlapping across the 2 psychotic disorders that...
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As a chronic psychiatric disorder, schizophrenia affects the worldwide population with a lifetime prevalence of 1% and considerable long-term mortality, morbidity, and burden. Besides the adverse effects of routine treatment regimens, a significant portion of patients remain symptomatic despite treatment, especially those with negative symptoms which are the major disabling factors in these pat...
متن کاملPsychosocial factors in the neurobiology of schizophrenia: a selective review.
AIM Various forms of social adversity have been implicated in the development and emergence of psychosis. However, how and when these events exert their influences are not clear. In this paper, we attempt to examine these putative psychosocial factors and place them in a temporal context and propose a neurobiological mechanism linking these factors. METHODS Medline databases were searched bet...
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Structural neuroimaging studies have provided some of the most consistent evidence for brain abnormalities in schizophrenia. Since the initial computed tomography study by Johnstone and co-workers, which reported lateral ventricular enlargement in schizophrenia, advances in brain imaging technology have enabled further and more refined characterization of abnormal brain structure in schizophren...
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ژورنال
عنوان ژورنال: Schizophrenia Research
سال: 2009
ISSN: 0920-9964
DOI: 10.1016/j.schres.2009.01.016